新規更新November 23, 2018 at 12:58PM
【外部リンク】
Wellcome Trust Case Control Consortium
IntoThinAir: add recognition for 2007 paper Reference edited with ProveIt
The '''Wellcome Trust Case Control Consortium''' (abbreviated '''WTCCC''') is a collaboration between fifty research groups in the [[United Kingdom]] in the field of [[human genetics]]. Established in 2005, the WTCCC aims to conduct [[genome-wide association studies]] (GWASs) to shed light on the [[genetic architecture]] of common [[human disease]]s.<ref></ref> The founding chairman of the consortium was [[University of Oxford]] statistician [[Peter Donnelly]]. The consortium was funded by £9 million from the [[Wellcome Trust]].<ref name=pr/> According to the consortium's website, it has identified "approximately 90" new susceptibility [[genetic locus|loci]] for common human diseases.<ref></ref>
The consortium's initial goal was to conduct large GWASs for eight common human diseases: [[tuberculosis]], [[coronary heart disease]], [[type 1 diabetes]], [[type 2 diabetes]], [[rheumatoid arthritis]], [[Crohn's disease]] and [[ulcerative colitis]], [[bipolar disorder]] and [[hypertension]]. These GWASs included a total of 19,000 subjects, of whom 2,000 had one of the eight diseases and an additional 3,000 served as controls.<ref name=pr>Liquid error: wrong number of arguments (1 for 2)</ref> The study participants were [[genotyping|genotyped]] using [[Affymetrix]]'s GeneChip Human Mapping 500K Array Set, and genotype calling was conducted with the Chiamo [[algorithm]].<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
The results of the WTCCC's initial research were reported in ''[[Nature (journal)|Nature]]'' in 2007. The research identified 24 genetic association "signals" that were [[statistically significant]] at ''[[p-value|P]]'' < 5 × 10<sup>-7</sup>.<ref>Liquid error: wrong number of arguments (1 for 2)</ref><ref>Liquid error: wrong number of arguments (1 for 2)</ref> At the time, this was the largest study ever conducted of the genetics of human diseases.<ref>Liquid error: wrong number of arguments (1 for 2)</ref> In announcing the study's findings at a [[London]] news conference, Donnelly said, "If you think of the genome as a very long road that you are trying to find your way along in the dark, previously we have only been able to turn lights on in a small number of places, but now we can turn on lights in a large number of places— in this case half a million lights".<ref>Liquid error: wrong number of arguments (1 for 2)</ref> The 2007 ''Nature'' paper was later named "paper of the year" by ''[[the Lancet]]'',<ref>Liquid error: wrong number of arguments (1 for 2)</ref> and it led to the WTCCC being named "research leader of the year" by ''[[Scientific American]]''.<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
==References==
==External links==
*
[[Category:Scientific organizations established in 2005]]
[[Category:Research projects]]
[[Category:Wellcome Trust]]
[[Category:2005 establishments in England]]
[[Category:Scientific organisations based in the United Kingdom]]
[[Category:Genetic epidemiology]]
The consortium's initial goal was to conduct large GWASs for eight common human diseases: [[tuberculosis]], [[coronary heart disease]], [[type 1 diabetes]], [[type 2 diabetes]], [[rheumatoid arthritis]], [[Crohn's disease]] and [[ulcerative colitis]], [[bipolar disorder]] and [[hypertension]]. These GWASs included a total of 19,000 subjects, of whom 2,000 had one of the eight diseases and an additional 3,000 served as controls.<ref name=pr>Liquid error: wrong number of arguments (1 for 2)</ref> The study participants were [[genotyping|genotyped]] using [[Affymetrix]]'s GeneChip Human Mapping 500K Array Set, and genotype calling was conducted with the Chiamo [[algorithm]].<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
The results of the WTCCC's initial research were reported in ''[[Nature (journal)|Nature]]'' in 2007. The research identified 24 genetic association "signals" that were [[statistically significant]] at ''[[p-value|P]]'' < 5 × 10<sup>-7</sup>.<ref>Liquid error: wrong number of arguments (1 for 2)</ref><ref>Liquid error: wrong number of arguments (1 for 2)</ref> At the time, this was the largest study ever conducted of the genetics of human diseases.<ref>Liquid error: wrong number of arguments (1 for 2)</ref> In announcing the study's findings at a [[London]] news conference, Donnelly said, "If you think of the genome as a very long road that you are trying to find your way along in the dark, previously we have only been able to turn lights on in a small number of places, but now we can turn on lights in a large number of places— in this case half a million lights".<ref>Liquid error: wrong number of arguments (1 for 2)</ref> The 2007 ''Nature'' paper was later named "paper of the year" by ''[[the Lancet]]'',<ref>Liquid error: wrong number of arguments (1 for 2)</ref> and it led to the WTCCC being named "research leader of the year" by ''[[Scientific American]]''.<ref>Liquid error: wrong number of arguments (1 for 2)</ref>
==References==
==External links==
*
[[Category:Scientific organizations established in 2005]]
[[Category:Research projects]]
[[Category:Wellcome Trust]]
[[Category:2005 establishments in England]]
[[Category:Scientific organisations based in the United Kingdom]]
[[Category:Genetic epidemiology]]
https://ift.tt/2R7Ox0T
