新規更新December 31, 2019 at 12:03PM
【外部リンク】
Lipoprotein lipase
Le-cerveau-gelé:
'''Lipoprotein lipase''' ( '''LPL''' ) ( ) là thành viên của họ gen quy định [[lipase]], gồm [[Họ lipase tụy|lipase tụy]], [[lipase gan]] và [[lipase nội mô]] . LPL là một [[Enzym|enzyme]] hòa tan trong nước, [[thủy phân]] [[Triglyceride|chất béo trung tính]] trong [[lipoprotein]] (chất có trong [[ Chylomicron |chylomicrons]] và [[Lipoprotein mật độ rất thấp|lipoprotein mật độ rất thấp (VLDL)]]), thành hai [[axit béo]] tự do và một phân tử [[ Monoacylglycerol |monoacylglycerol]] . Enzyme liên quan đến sự hấp thu những mảnh còn sót lại của chylomicron, lipoprotein giàu cholesterol và axit béo tự do của tế bào. <ref name="Mead-2002">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Rinninger-1998">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Ma-1994">Liquid error: wrong number of arguments (given 1, expected 2)</ref> [[ ApoC-II |ApoC-II]] là cofactor của LPL. <ref name="pmid16314153">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Kinnunen-1977">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
LPL được gắn vào mặt trong của [[tế bào nội mô]] trong [[mao mạch]] nhờ protein glycosylphosphatidylinositol HDL-gắn-protein 1 (GPIHBP1) và bởi các peptidoglycan được heparan sulfate hóa. <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> Enzyme được tìm thấy nhiều trong mô mỡ, tim và mô [[cơ xương]], tuyến vú. <ref name="Wang-1992">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Wong-2002">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Braun-1992">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Tổng hợp ==
Tóm lại, LPL tiết ra từ [[Nhu mô|các tế bào nhu mô]] ở tim, cơ và mỡ dưới dạng homodimer được [[glycosyl hóa]], sau đó nó di chuyển qua [[Cấu trúc nền của da|chất nền ngoại bào]] và tế bào nội mô đến màng trong mao mạch. Sau khi dịch mã, protein mới được tổng hợp được glycosyl hóa trong [[mạng lưới nội chất]] . Các vị trí glycosyl hóa của LPL là Asn-43, Asn-257 và Asn-359. <ref name="Mead-2002">Liquid error: wrong number of arguments (given 1, expected 2)</ref> [[ Glucosidase |Glucosidase]] cắt bỏ glucose; việc cắt glucose này chịu trách nhiệm cho sự thay đổi về hình dạng nhằm hoạt hóa hoạt động xúc tác của LPL dưới dạng hai cấu phần protein giống nhau (''homodimer''). <ref name="Braun-1992">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Semb-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Wong-1994">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Trong [[Bộ máy Golgi|bộ Golgi]], các [[Oligosaccharide|oligosaccharid]] được thay đổi tạo hai chuỗi phức, hoặc hai chuỗi phức và một chuỗi mannose cao phân tử. Trong hình dạng protein cuối cùng, carbohydrate chiếm khoảng 12% khối lượng phân tử (55-58 kDa). <ref name="Vannier-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
Sự tạo thành hai cấu phần protein giống nhau (''Homodimerization'' ) là cần thiết trước khi LPL xuất bào. <ref name="Vannier-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Ong-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Sau giai đoạn xuất bào, LPL đi qua các tế bào nội mô và chui vào trong mao mạch nhờ protein [[ Glycosylphosphatidylinositol |glycosylphosphatidylinositol]] - một loại protein gắn lipoprotein mật độ cao type 1. <ref name="pmid17403372"></ref> <ref name="pmid20620994">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Kết cấu ==
[[Cấu trúc tinh thể]] của LPL khá phức tap. <ref name="pmid30559189">; Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="pmid31072929">; Liquid error: wrong number of arguments (given 1, expected 2)</ref> Cấu thành của LPL gồm hai vùng riêng biệt: miền đầu-N lớn hơn có chứa vị trí [[Vị trí hoạt động|hoạt động]] lipolytic và miền đầu-C nhỏ hơn. Hai vùng này gắn với nhau bởi một liên kết peptide. Miền đầu-N có [[Siêu họ α/β hydrolase|nếp gấp α/β hydrolase]], đây là cấu trúc hình cầu chứa một [[gấp nếp β]] trung tâm được [[xoắn α]] bao xung quanh. Miền đầu-C có hình sandwich β, hình thành bởi hai tấm β giống một hình trụ thuôn dài.
== Ý nghĩa lâm sàng ==
[[Thiếu lipoprotein lipase]] dẫn đến [[tăng triglyceride máu]]. <ref name="pmid17706445">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Ở chuột, sự biểu hiện quá mức của LPL đã được chứng minh là gây [[kháng insulin]], <ref name="pmid11334409"></ref> <ref name="pmid11390966"></ref> gây béo phì. <ref name="pmid22562834"></ref>
Một phản ứng LPL mô mỡ cao đối với chế độ ăn nhiều carbohydrate dẫn đến tăng mỡ. Một nghiên cứu báo cáo rằng các đối tượng tăng mỡ trong bốn năm, nếu sau khi thực hiện chế độ ăn nhiều carbohydrate, họ đã phản ứng với sự gia tăng hoạt động LPL mô mỡ trên mỗi tế bào mỡ hoặc giảm hoạt động LPL cơ xương. <ref name="Ferland,2012">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
Biểu hiện LPL đã được chứng minh là một yếu tố tiên lượng trong [[Bệnh bạch cầu lympho bào mạn tính|bệnh bạch cầu lympho bào mãn tính]] . <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> Trong rối loạn huyết học này, LPL có vẻ như là nguồn cung cấp axit béo với vai trò nguồn năng lượng cho các tế bào ác tính. <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> Do đó, nồng độ LPL mRNA hoặc protein tăng cao được coi là chỉ số tiên lượng xấu. <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Trong các sinh vật khác ==
Gen LPL có trong các động vật có xương sống. Lipoprotein lipase có liên quan đến việc vận chuyển lipid trong nhau thai của thằn lằn ''[[Pseudemoia entrecasteauxii]]''. <ref name="pmid23939756">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Bản đồ đường tương tác ==
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<div style="position:absolute; left:0px; top:0px; line-height:110% "><span style="background-color:transparent; ">[[<div style="display:block; width:53px; height:12px;
overflow:hidden; position:relative; left:359.0px; top:331.5px;
background:transparent; border:4px black solid"><nowiki></div></nowiki>]]
</span></div>
</div>
<div style="visibility:hidden"><imagemap>
Image:StatinPathway_WP430.png|right|alt=Statin_Pathway_WP430
rect 128.8 125.7 188.8 145.7 [[HMGCR|go to article]]
rect 348.0 150.5 398.5 170.5 [[CYP7A1|go to article]]
rect 396.2 184.7 456.2 204.7 [[SOAT1|go to article]]
rect 664.0 141.8 724.0 161.8 [[Dgat1|go to article]]
rect 159.2 315.3 219.2 335.3 [[LDL_receptor|go to article]]
rect 446.0 317.8 506.0 337.8 [[SCARB1|go to article]]
rect 287.5 314.8 347.5 334.8 [[LRP1|go to article]]
rect 359.0 343.5 419.0 363.5 [[Lipoprotein_lipase|go to article]]
rect 207.3 398.0 267.3 418.0 [[Hepatic_lipase|go to article]]
rect 281.3 435.8 341.3 455.8 [[Cholesterylester_transfer_protein|go to article]]
rect 303.3 493.5 363.3 513.5 [[Lecithin-cholesterol_acyltransferase|go to article]]
rect 304.3 606.3 364.3 626.3 [[ABCA1|go to article]]
rect 522.2 451.2 582.2 471.2 [[Apolipoprotein_A1|go to article]]
rect 468.2 536.0 528.2 556.0 [[APOA4|go to article]]
rect 608.7 419.8 668.7 439.8 [[APOC1|go to article]]
rect 608.7 399.8 668.7 419.8 [[Apolipoprotein_E|go to article]]
rect 668.7 399.8 728.7 419.8 [[APOC2|go to article]]
rect 668.7 419.8 728.7 439.8 [[Apolipoprotein_C3|go to article]]
rect 522.2 431.2 582.2 451.2 [[PLTP|go to article]]
rect 268.3 218.5 361.7 237.5 [[Cholesterol|go to article]]
rect 280.8 104.3 350.0 123.3 [[Cholic_acid|go to article]]
rect 194.2 619.7 262.5 638.7 [[Cholesterol|go to article]]
rect 50.3 71.0 115.3 91.0 [[Acetyl-coa|go to article]]
rect 470.0 218.0 555.0 238.0 [[Cholesteryl_ester|go to article]]
rect 410.5 113.5 465.5 133.5 [[Fatty_acid|go to article]]
rect 559.0 194.0 633.5 214.0 [[Phospholipid|go to article]]
rect 654.5 230.0 734.5 250.0 [[Triglyceride|go to article]]
rect 134.5 361.5 166.5 381.5 [[LDL|go to article]]
rect 299.0 361.5 331.0 381.5 [[Intermediate_density_lipoprotein|go to article]]
rect 414.5 382.5 446.5 402.5 [[VLDL|go to article]]
rect 386.0 446.5 418.0 466.5 [[High-density_lipoprotein|go to article]]
rect 125.3 555.0 185.3 575.0 [[ABCG5|go to article]]
rect 125.3 575.0 185.3 595.0 [[ABCG8|go to article]]
rect 413.2 605.3 473.2 625.3 [[ABCA1|go to article]]
rect 508.7 621.7 577.0 640.7 [[Cholesterol|go to article]]
rect 608.7 439.8 668.7 459.8 [[Apolipoprotein_B|go to article]]
rect 668.7 439.8 728.7 459.8 [[APOA5|go to article]]
rect 572.3 314.0 621.3 334.0 [[Microsomal_triglyceride_transfer_protein|go to article]]
rect 582.5 95.5 628.5 115.5 [[Diglyceride|go to article]]
rect 127.0 218.0 194.0 238.0 [[Squalene|go to article]]
rect 40.3 245.0 91.0 265.0 [[Farnesyl-diphosphate_farnesyltransferase|go to article]]
rect 202.0 181.0 245.0 201.0 [[Squalene_monooxygenase|go to article]]
rect 497.8 113.8 551.5 133.8 [[Acyl-CoA|go to article]]
rect 430.5 75.5 532.5 95.5 [[Acyl-CoA_synthetase|go to article]]
rect 572.3 294.0 621.3 314.0 [[Protein_disulfide-isomerase|go to article]]
rect 359.2 541.2 427.5 560.2 [[Cholesterol|go to article]]
rect 522.2 471.2 582.2 491.2 [[APOA2|go to article]]
rect 348.2 665.8 428.2 685.8 [[MiR-33|go to article]]
rect 348.2 685.8 428.2 705.8 [[MiR-33|go to article]]
default [[Statin#Other_effects|Go to pathway article]]
desc none
</imagemap></div>
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</div></div>|px|alt=Statin Pathway [https://ift.tt/37rMw7t edit]]]</div></div>
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<div class="magnify"> </div>Statin Pathway [https://ift.tt/37rMw7t edit]
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<div style="clear:both;"></div><div class="reflist " style=" list-style-type: decimal;">
<references group="§" responsive="1"></references></div>
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== Nguồn tham khảo ==
== Đọc thêm ==
*
*
*
*
*Liquid error: wrong number of arguments (given 1, expected 2)
*Liquid error: wrong number of arguments (given 1, expected 2)
== Liên kết ngoài ==
* [https://ift.tt/39pmVO8 Mục nhập GeneReview / NCBI / NIH / UW về sự thiếu hụt lipoprotein Lipoprotein gia đình]
* [https://ift.tt/37kuJyX Liệu pháp gen cho thiếu hụt lipoprotein lipase]
*
LPL được gắn vào mặt trong của [[tế bào nội mô]] trong [[mao mạch]] nhờ protein glycosylphosphatidylinositol HDL-gắn-protein 1 (GPIHBP1) và bởi các peptidoglycan được heparan sulfate hóa. <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> Enzyme được tìm thấy nhiều trong mô mỡ, tim và mô [[cơ xương]], tuyến vú. <ref name="Wang-1992">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Wong-2002">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Braun-1992">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Tổng hợp ==
Tóm lại, LPL tiết ra từ [[Nhu mô|các tế bào nhu mô]] ở tim, cơ và mỡ dưới dạng homodimer được [[glycosyl hóa]], sau đó nó di chuyển qua [[Cấu trúc nền của da|chất nền ngoại bào]] và tế bào nội mô đến màng trong mao mạch. Sau khi dịch mã, protein mới được tổng hợp được glycosyl hóa trong [[mạng lưới nội chất]] . Các vị trí glycosyl hóa của LPL là Asn-43, Asn-257 và Asn-359. <ref name="Mead-2002">Liquid error: wrong number of arguments (given 1, expected 2)</ref> [[ Glucosidase |Glucosidase]] cắt bỏ glucose; việc cắt glucose này chịu trách nhiệm cho sự thay đổi về hình dạng nhằm hoạt hóa hoạt động xúc tác của LPL dưới dạng hai cấu phần protein giống nhau (''homodimer''). <ref name="Braun-1992">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Semb-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Wong-1994">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Trong [[Bộ máy Golgi|bộ Golgi]], các [[Oligosaccharide|oligosaccharid]] được thay đổi tạo hai chuỗi phức, hoặc hai chuỗi phức và một chuỗi mannose cao phân tử. Trong hình dạng protein cuối cùng, carbohydrate chiếm khoảng 12% khối lượng phân tử (55-58 kDa). <ref name="Vannier-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
Sự tạo thành hai cấu phần protein giống nhau (''Homodimerization'' ) là cần thiết trước khi LPL xuất bào. <ref name="Vannier-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="Ong-1989">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Sau giai đoạn xuất bào, LPL đi qua các tế bào nội mô và chui vào trong mao mạch nhờ protein [[ Glycosylphosphatidylinositol |glycosylphosphatidylinositol]] - một loại protein gắn lipoprotein mật độ cao type 1. <ref name="pmid17403372"></ref> <ref name="pmid20620994">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Kết cấu ==
[[Cấu trúc tinh thể]] của LPL khá phức tap. <ref name="pmid30559189">; Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref name="pmid31072929">; Liquid error: wrong number of arguments (given 1, expected 2)</ref> Cấu thành của LPL gồm hai vùng riêng biệt: miền đầu-N lớn hơn có chứa vị trí [[Vị trí hoạt động|hoạt động]] lipolytic và miền đầu-C nhỏ hơn. Hai vùng này gắn với nhau bởi một liên kết peptide. Miền đầu-N có [[Siêu họ α/β hydrolase|nếp gấp α/β hydrolase]], đây là cấu trúc hình cầu chứa một [[gấp nếp β]] trung tâm được [[xoắn α]] bao xung quanh. Miền đầu-C có hình sandwich β, hình thành bởi hai tấm β giống một hình trụ thuôn dài.
== Ý nghĩa lâm sàng ==
[[Thiếu lipoprotein lipase]] dẫn đến [[tăng triglyceride máu]]. <ref name="pmid17706445">Liquid error: wrong number of arguments (given 1, expected 2)</ref> Ở chuột, sự biểu hiện quá mức của LPL đã được chứng minh là gây [[kháng insulin]], <ref name="pmid11334409"></ref> <ref name="pmid11390966"></ref> gây béo phì. <ref name="pmid22562834"></ref>
Một phản ứng LPL mô mỡ cao đối với chế độ ăn nhiều carbohydrate dẫn đến tăng mỡ. Một nghiên cứu báo cáo rằng các đối tượng tăng mỡ trong bốn năm, nếu sau khi thực hiện chế độ ăn nhiều carbohydrate, họ đã phản ứng với sự gia tăng hoạt động LPL mô mỡ trên mỗi tế bào mỡ hoặc giảm hoạt động LPL cơ xương. <ref name="Ferland,2012">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
Biểu hiện LPL đã được chứng minh là một yếu tố tiên lượng trong [[Bệnh bạch cầu lympho bào mạn tính|bệnh bạch cầu lympho bào mãn tính]] . <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> Trong rối loạn huyết học này, LPL có vẻ như là nguồn cung cấp axit béo với vai trò nguồn năng lượng cho các tế bào ác tính. <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> Do đó, nồng độ LPL mRNA hoặc protein tăng cao được coi là chỉ số tiên lượng xấu. <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref> <ref>Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Trong các sinh vật khác ==
Gen LPL có trong các động vật có xương sống. Lipoprotein lipase có liên quan đến việc vận chuyển lipid trong nhau thai của thằn lằn ''[[Pseudemoia entrecasteauxii]]''. <ref name="pmid23939756">Liquid error: wrong number of arguments (given 1, expected 2)</ref>
== Bản đồ đường tương tác ==
<div style="overflow:auto; ">
<div class="thumb tleft">
<div class="thumbinner" style="width: 377px;">
<div class="thumbimage" style="width: 375px; height: 350px; overflow: hidden;">
<div style="position: relative; top: -203.5px; left: -211.5px; width: px"><div class="noresize">[[File:<div class="noresize thumb tnone" style="; ">
<div class="thumbinner" style="overflow:hidden;width:830px;">
<div class="thumbimage" style=" overflow:hidden; position:relative; background-color:white;">
<div style=";left:0px; top:0px; width:828px; position:absolute;"> <imagemap>
Image:StatinPathway_WP430.png|right|alt=Statin_Pathway_WP430
rect 128.8 125.7 188.8 145.7 [[HMGCR|go to article]]
rect 348.0 150.5 398.5 170.5 [[CYP7A1|go to article]]
rect 396.2 184.7 456.2 204.7 [[SOAT1|go to article]]
rect 664.0 141.8 724.0 161.8 [[Dgat1|go to article]]
rect 159.2 315.3 219.2 335.3 [[LDL_receptor|go to article]]
rect 446.0 317.8 506.0 337.8 [[SCARB1|go to article]]
rect 287.5 314.8 347.5 334.8 [[LRP1|go to article]]
rect 359.0 343.5 419.0 363.5 [[Lipoprotein_lipase|go to article]]
rect 207.3 398.0 267.3 418.0 [[Hepatic_lipase|go to article]]
rect 281.3 435.8 341.3 455.8 [[Cholesterylester_transfer_protein|go to article]]
rect 303.3 493.5 363.3 513.5 [[Lecithin-cholesterol_acyltransferase|go to article]]
rect 304.3 606.3 364.3 626.3 [[ABCA1|go to article]]
rect 522.2 451.2 582.2 471.2 [[Apolipoprotein_A1|go to article]]
rect 468.2 536.0 528.2 556.0 [[APOA4|go to article]]
rect 608.7 419.8 668.7 439.8 [[APOC1|go to article]]
rect 608.7 399.8 668.7 419.8 [[Apolipoprotein_E|go to article]]
rect 668.7 399.8 728.7 419.8 [[APOC2|go to article]]
rect 668.7 419.8 728.7 439.8 [[Apolipoprotein_C3|go to article]]
rect 522.2 431.2 582.2 451.2 [[PLTP|go to article]]
rect 268.3 218.5 361.7 237.5 [[Cholesterol|go to article]]
rect 280.8 104.3 350.0 123.3 [[Cholic_acid|go to article]]
rect 194.2 619.7 262.5 638.7 [[Cholesterol|go to article]]
rect 50.3 71.0 115.3 91.0 [[Acetyl-coa|go to article]]
rect 470.0 218.0 555.0 238.0 [[Cholesteryl_ester|go to article]]
rect 410.5 113.5 465.5 133.5 [[Fatty_acid|go to article]]
rect 559.0 194.0 633.5 214.0 [[Phospholipid|go to article]]
rect 654.5 230.0 734.5 250.0 [[Triglyceride|go to article]]
rect 134.5 361.5 166.5 381.5 [[LDL|go to article]]
rect 299.0 361.5 331.0 381.5 [[Intermediate_density_lipoprotein|go to article]]
rect 414.5 382.5 446.5 402.5 [[VLDL|go to article]]
rect 386.0 446.5 418.0 466.5 [[High-density_lipoprotein|go to article]]
rect 125.3 555.0 185.3 575.0 [[ABCG5|go to article]]
rect 125.3 575.0 185.3 595.0 [[ABCG8|go to article]]
rect 413.2 605.3 473.2 625.3 [[ABCA1|go to article]]
rect 508.7 621.7 577.0 640.7 [[Cholesterol|go to article]]
rect 608.7 439.8 668.7 459.8 [[Apolipoprotein_B|go to article]]
rect 668.7 439.8 728.7 459.8 [[APOA5|go to article]]
rect 572.3 314.0 621.3 334.0 [[Microsomal_triglyceride_transfer_protein|go to article]]
rect 582.5 95.5 628.5 115.5 [[Diglyceride|go to article]]
rect 127.0 218.0 194.0 238.0 [[Squalene|go to article]]
rect 40.3 245.0 91.0 265.0 [[Farnesyl-diphosphate_farnesyltransferase|go to article]]
rect 202.0 181.0 245.0 201.0 [[Squalene_monooxygenase|go to article]]
rect 497.8 113.8 551.5 133.8 [[Acyl-CoA|go to article]]
rect 430.5 75.5 532.5 95.5 [[Acyl-CoA_synthetase|go to article]]
rect 572.3 294.0 621.3 314.0 [[Protein_disulfide-isomerase|go to article]]
rect 359.2 541.2 427.5 560.2 [[Cholesterol|go to article]]
rect 522.2 471.2 582.2 491.2 [[APOA2|go to article]]
rect 348.2 665.8 428.2 685.8 [[MiR-33|go to article]]
rect 348.2 685.8 428.2 705.8 [[MiR-33|go to article]]
default [[Statin#Other_effects|Go to pathway article]]
desc none
</imagemap></div>
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<div style="position:absolute; left:0px; top:0px; line-height:110% "><span style="background-color:transparent; ">[[<div style="display:block; width:80px; height:0px; overflow:hidden; position:relative; left:348.2px; top:690.8px; background:transparent; border-top:3px blue solid"></div>]]</span></div>
<div style="position:absolute; left:0px; top:0px; line-height:110% "><span style="background-color:transparent; ">[[<div style="display:block; width:53px; height:12px;
overflow:hidden; position:relative; left:359.0px; top:331.5px;
background:transparent; border:4px black solid"><nowiki></div></nowiki>]]
</span></div>
</div>
<div style="visibility:hidden"><imagemap>
Image:StatinPathway_WP430.png|right|alt=Statin_Pathway_WP430
rect 128.8 125.7 188.8 145.7 [[HMGCR|go to article]]
rect 348.0 150.5 398.5 170.5 [[CYP7A1|go to article]]
rect 396.2 184.7 456.2 204.7 [[SOAT1|go to article]]
rect 664.0 141.8 724.0 161.8 [[Dgat1|go to article]]
rect 159.2 315.3 219.2 335.3 [[LDL_receptor|go to article]]
rect 446.0 317.8 506.0 337.8 [[SCARB1|go to article]]
rect 287.5 314.8 347.5 334.8 [[LRP1|go to article]]
rect 359.0 343.5 419.0 363.5 [[Lipoprotein_lipase|go to article]]
rect 207.3 398.0 267.3 418.0 [[Hepatic_lipase|go to article]]
rect 281.3 435.8 341.3 455.8 [[Cholesterylester_transfer_protein|go to article]]
rect 303.3 493.5 363.3 513.5 [[Lecithin-cholesterol_acyltransferase|go to article]]
rect 304.3 606.3 364.3 626.3 [[ABCA1|go to article]]
rect 522.2 451.2 582.2 471.2 [[Apolipoprotein_A1|go to article]]
rect 468.2 536.0 528.2 556.0 [[APOA4|go to article]]
rect 608.7 419.8 668.7 439.8 [[APOC1|go to article]]
rect 608.7 399.8 668.7 419.8 [[Apolipoprotein_E|go to article]]
rect 668.7 399.8 728.7 419.8 [[APOC2|go to article]]
rect 668.7 419.8 728.7 439.8 [[Apolipoprotein_C3|go to article]]
rect 522.2 431.2 582.2 451.2 [[PLTP|go to article]]
rect 268.3 218.5 361.7 237.5 [[Cholesterol|go to article]]
rect 280.8 104.3 350.0 123.3 [[Cholic_acid|go to article]]
rect 194.2 619.7 262.5 638.7 [[Cholesterol|go to article]]
rect 50.3 71.0 115.3 91.0 [[Acetyl-coa|go to article]]
rect 470.0 218.0 555.0 238.0 [[Cholesteryl_ester|go to article]]
rect 410.5 113.5 465.5 133.5 [[Fatty_acid|go to article]]
rect 559.0 194.0 633.5 214.0 [[Phospholipid|go to article]]
rect 654.5 230.0 734.5 250.0 [[Triglyceride|go to article]]
rect 134.5 361.5 166.5 381.5 [[LDL|go to article]]
rect 299.0 361.5 331.0 381.5 [[Intermediate_density_lipoprotein|go to article]]
rect 414.5 382.5 446.5 402.5 [[VLDL|go to article]]
rect 386.0 446.5 418.0 466.5 [[High-density_lipoprotein|go to article]]
rect 125.3 555.0 185.3 575.0 [[ABCG5|go to article]]
rect 125.3 575.0 185.3 595.0 [[ABCG8|go to article]]
rect 413.2 605.3 473.2 625.3 [[ABCA1|go to article]]
rect 508.7 621.7 577.0 640.7 [[Cholesterol|go to article]]
rect 608.7 439.8 668.7 459.8 [[Apolipoprotein_B|go to article]]
rect 668.7 439.8 728.7 459.8 [[APOA5|go to article]]
rect 572.3 314.0 621.3 334.0 [[Microsomal_triglyceride_transfer_protein|go to article]]
rect 582.5 95.5 628.5 115.5 [[Diglyceride|go to article]]
rect 127.0 218.0 194.0 238.0 [[Squalene|go to article]]
rect 40.3 245.0 91.0 265.0 [[Farnesyl-diphosphate_farnesyltransferase|go to article]]
rect 202.0 181.0 245.0 201.0 [[Squalene_monooxygenase|go to article]]
rect 497.8 113.8 551.5 133.8 [[Acyl-CoA|go to article]]
rect 430.5 75.5 532.5 95.5 [[Acyl-CoA_synthetase|go to article]]
rect 572.3 294.0 621.3 314.0 [[Protein_disulfide-isomerase|go to article]]
rect 359.2 541.2 427.5 560.2 [[Cholesterol|go to article]]
rect 522.2 471.2 582.2 491.2 [[APOA2|go to article]]
rect 348.2 665.8 428.2 685.8 [[MiR-33|go to article]]
rect 348.2 685.8 428.2 705.8 [[MiR-33|go to article]]
default [[Statin#Other_effects|Go to pathway article]]
desc none
</imagemap></div>
</div>
<div class="thumbcaption"></div>
</div></div>|px|alt=Statin Pathway [https://ift.tt/37rMw7t edit]]]</div></div>
</div>
<div class="thumbcaption">
<div class="magnify"> </div>Statin Pathway [https://ift.tt/37rMw7t edit]
</div>
</div>
</div>
<div style="clear:both;"></div><div class="reflist " style=" list-style-type: decimal;">
<references group="§" responsive="1"></references></div>
</div>
== Nguồn tham khảo ==
== Đọc thêm ==
*
*
*
*
*Liquid error: wrong number of arguments (given 1, expected 2)
*Liquid error: wrong number of arguments (given 1, expected 2)
== Liên kết ngoài ==
* [https://ift.tt/39pmVO8 Mục nhập GeneReview / NCBI / NIH / UW về sự thiếu hụt lipoprotein Lipoprotein gia đình]
* [https://ift.tt/37kuJyX Liệu pháp gen cho thiếu hụt lipoprotein lipase]
*
https://ift.tt/39rBHUF
